The sequence makes no difference as long as you do a thorough job. Look for products that have the ADA's Seal of Acceptance. Choose a toothbrush that feels comfortable in your hand and in your mouth, and use it twice a day. While tooth brushing removes plaque from tooth surfaces, it can't do the entire job of removing plaque. Cleaning between the teeth daily with floss or other interdental cleaners removes debris from between the teeth, where your toothbrush cannot reach. An ADA-Accepted dental floss or interdental cleaner is recommended.